Hereditary hemochromatosis associated with the development of liver cirrhosis

ABSTRACT Hereditary hemochromatosis (HH) is an autosomal recessive disease, most often associated with mutations in the HFE gene, which result continuous absorption of iron, causing its overload. Liver tissue main site iron deposition; thus, high levels when interacting oxygen, induce formation free radicals that will act on proteins, lipids, and deoxyribonucleic acid (DNA), may trigger deleterious effects at cellular levels. In order to elucidate development progression liver cirrhosis due overload, purpose this study describe pathophysiology hepatic system patients diagnosed HH. For purpose, searches for scientific articles were carried out academic databases. We found HH are more likely develop cirrhosis, since chronic deposition induces injury consequent regeneration, progressing collagen fibers synthesis surrounding hepatocytes, leading loss function cirrhosis. Therefore, it necessary carry tests such as ferritin transferrin measurements, evaluate body’s stores, aiming early diagnosis thus avoiding damage